Monday, March 20, 2006

Why H5N1 is such a Killer

here is a little more detail on how this flu kills:

"Why this new virus is so deadly is not entirely understood, although scientists have hints.

Influenza viruses invade cells lining the throat and windpipe, where they replicate and cause inflammation but are eventually suppressed by the immune system. In some cases, the microbe invades the lungs and leads to viral or bacterial pneumonia. Some H5N1 strains, however, have two features that make them even more dangerous.

Normally, the flu viruses can replicate only in the throat and lungs. With H5N1, however, the protein that triggers replication can be activated in many other organs, including the liver, intestines and brain. What is usually a respiratory infection can suddenly become a whole-body infection. Simultaneously, a second "defect" in the virus unleashes a storm of immune-system chemicals called cytokines. In normal amounts, cytokines help fight microbial invade
rs. In excessive amounts, they can cause lethal damage to the body's own tissues."

full article: http://www.washingtonpost.com/wp-dyn/content/article/2005/08/22/AR2005082201365.html

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